Universität zu Köln 

Prof. Dr. Maria Leptin

Institut für Genetik, Universität zu Köln
email: mleptin@uni-koeln.de
phone: +49-(0)221 470 3401
website

Running time: 2003 – 2011

Abstract

We have identified a novel phosphotyrosine motif on the FGF-signal transduction adapter Dof and have shown that it is involved in signal transmission. The motif is conserved in Dof from other insects and also in a number of signal transduction molecules in mammals, among them the Dof-related signalling molecule BANK and the FGF-receptor. We plan to determine the binding partners for this phosphotyrosine and to elucidate the mechanisms by which it couples Dof to downstream FGF-targets, with particular emphasis on modifications of adherens junction proteins that are mediated by FGF signalling.

(A final report will follow.)

Publications resulting from the project:

Baer, M.M., Bilstein, A., Caussinus E., Csiszar, A., Affolter, M., and Leptin, M. (2010). The role of apoptosis in shaping the tracheal system in the Drosophila embryo. Mech. Dev. 127, 28-35.

Csiszar, A., Vogelsang, E., Beug, H., and Leptin, M. (2010). A novel conserved phosphotyrosine motif in the Drosophila FGF-signalling adaptor Dof with a redundant role in signal transmission. Mol Cell Biol. 30, 2017-27.

Chanut-Delalande, H., Jung, A.C., Lin, L., Baer, M.M., Bilstein, A., Cabernard, C., Leptin, M., and Affolter M. (2007). A genetic MARCM screen to identify genes involved in tracheal cell migration during Drosophila air sac morphogenesis. Genetics 176, 2177-87.

Baer, M.M., Bilstein, A., and Leptin, M. (2007). A clonal genetic screen for mutants causing defects in larval tracheal morphogenesis in Drosophila. Genetics 176, 2279-9